Altered functional connectivity during speech perception in congenital amusia

Altered functional connectivity during speech perception in congenital amusia

Blog Article

Individuals with congenital amusia have a lifelong history of unreliable pitch processing.Accordingly, they downweight pitch cues during speech perception and instead rely on other dimensions L-CARNITINE such as duration.We investigated the neural basis for this strategy.During fMRI, individuals with amusia (N = 15) and controls (N = 15) read sentences where a comma indicated a grammatical phrase boundary.They then heard two sentences spoken that differed only in pitch and/or duration cues and selected the best match for the written sentence.

Prominent reductions in functional connectivity were detected in the amusia group between left prefrontal language-related regions and right hemisphere pitch-related regions, which reflected the between-group differences in cue weights in hardware the same groups of listeners.Connectivity differences between these regions were not present during a control task.Our results indicate that the reliability of perceptual dimensions is linked with functional connectivity between frontal and perceptual regions and suggest a compensatory mechanism.